It happened all the way back with Moria was still alive and Magneto became cloned, the first time and had to artificially age, he was consideribly younger afterwards. Then he got cloned the second time by some crazy biatch. But by that time, he should be at least in his body should be in the late 50's by now after all that time messing. But then again, not alot of time has passed in the Marvelverse. Considering Cap. America's body is still much younger over Mag, Cable and Doctor Strange.